Gastric Secretory Studies
نویسنده
چکیده
This study compares the gastroprotective effects of colloidal bismuth subcitrate (DeNol) with those of sucralfate and a methylated analogue of prostaglandin E2 (PGE2) against acute gastric lesions induced by acidified aspirin and absolute ethanol in rats. Both De-Nol and sucralfate given orally prevented dose dependently the formation of gastric lesions by these ulcerogens, DeNol being, respectively, twice and seven times more potent, on a weight basis, than sucralfate. As the gastroprotective activities of both De-Nol and sucralfate on ethanol lesions can be reversed by pretreatment with indomethacin and as De-Nol and sucralfate increase the mucosal generation and luminal release of PGE2, we postulate that mucosal prostaglandins may be involved in the mechanism of action of these drugs on the gastric mucosa.
منابع مشابه
Anti-Ulcer and anti-secretory Properties of the Butea Monosperma (Lam) Bark Extract with Relation to anti-oxidant Studies
To investigate the ulcer protective and antisecretory properties of the methanolic extract of Butea monosperma (BM) bark with relation to antioxidant studies. The study was done on male albino rats. Gastric ulcers were induced by Aspirin, Alcohol and Pylorous ligation. Lansoprazole was used as the standard drug for comparison. The free radical scavenging potential of the bark of BM ...
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